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Your location: Home - NewsFor the diagnosis of malignant nanocapsules
Japanese researchers have developed a nano-capsule, the capsule can help diagnose cancer.
Polymersomes are nanometer-sized capsule, its structure is hollow. Researchers studied extensively for its role in the delivery of drugs. PICsomes Japan recently developed a new type of polymer vesicles, they are formed by mixing the electrolyte obtained positive and negative ions. PICsomes can survive for long periods in the blood which can be used to transport water-soluble substance to the target tissue. A study "Advanced Materials Science and Technology" magazine published noted, PICsomes can adapt to the environment in order to survive in blood for a long time, but also better able to hit the tumor cells. These features of PICsomes have good prospects in terms of the delivery of drugs and tumor image.
Cyclic RGD peptides are an important medium for the two receptors are connected together, play an important role in the formation of new blood vessels in tumors, which also makes it an excellent tumor tracker. ETAM in the study, Japanese researchers will cRGD and PICsomes together, and then injected into mice. The researchers found that cRGD-PICsomes appear in this new hemangioma, and where there may be more than 24 hours. Then researchers at the cRGD-PICsomes load superparamagnetic iron oxide, which can effectively improve the image quality of the body structure. In addition, glioblastoma is injected into the brains of mice, and there may be more than two weeks. Then load cRGD-PICsomes SPIO was injected into mice. By imaging techniques, the researchers successfully track in the vicinity of the tumor cells to the substance.
The study results show that, SPIO load cRGD-PICsomes can effectively improve the tumor microenvironment MRI contrast, so this technique in the field of imaging tumor cells have very important applications.